%0 Journal Article
%A Lafont, Alexandre
%A Sinnaeve, Peter R
%A Cuisset, Thomas
%A Cook, Stéphane
%A Sideris, Giorgios
%A Kedev, Sasko
%A Carrie, Didier
%A Hovasse, Thomas
%A Garot, Philippe
%A El Mahmoud, Rami
%A Spaulding, Christian
%A Helft, Gérard
%A Diaz Fernandez, José F
%A Brugaletta, Salvatore
%A Pinar-Bermudez, Eduardo
%A Ferre, Josepa Mauri
%A Commeau, Philippe
%A Teiger, Emmanuel
%A Bogaerts, Kris
%A Sabate, Manel
%A Morice, Marie Claude
%A Varenne, Olivier
%A SENIOR investigators
%T Two-year outcomes after percutaneous coronary intervention with drug-eluting stents or bare-metal stents in elderly patients with coronary artery disease.
%D 2020
%U http://hdl.handle.net/10668/16060
%X Report the results at 2 years of the patients included in the SENIOR trial. Patients above 75 years of age represent a fast-growing population in the cathlab. In the SENIOR trial, patients treated by percutaneous coronary intervention (PCI) with drug eluting stent (DES) and a short duration of P2Y12 inhibitor (1 and 6 months for stable and unstable coronary syndromes, respectively) compared with bare metal stents (BMS) was associated with a 29% reduction in the rate of all-cause mortality, myocardial infarction (MI), stroke, and ischaemia-driven target lesion revascularization (ID-TLR) at 1 year. The results at 2 years are reported here. We randomly assigned 1,200 patients (596[50%] to the DES group and 604[50%] to the BMS group). At 2 years, the composite endpoint of all-cause mortality, MI, stroke and ID-TLR had occurred in 116 (20%) patients in the DES group and 131 (22%) patients in the BMS group (RR 0.90 [95%CI 0.72-1.13], p = .37). IDTLR occurred in 14 (2%) patients in the DES group and 41 (7%) patients in the BMS group (RR 0.35 [95%CI 0.16-0.60], p = .0002). Major bleedings (BARC 3-5) occurred in 27(5%) patients in both groups (RR 1.00, [95%CI 0.58-1.75], p = .99). Stent thrombosis rates were low and similar between DES and BMS (0.8 vs 1.3%, (RR 0.52 [95%CI 0.01-1.95], p = .27). Among elderly PCI patients, a strategy combining a DES together with a short duration of DAPT is associated with a reduction in revascularization up to 2 years compared with BMS with very few late events and without any increased in bleeding complications or stent thrombosis.
%K PCI
%K bare metal stents
%K drug eluting stents
%K elderly patients
%K short DAPT
%~