TY  - JOUR
AU  - Perez-Villegas, Eva M
AU  - Perez-Rodriguez, Mikel
AU  - Negrete-Diaz, Jose V
AU  - Ruiz, Rocio
AU  - Rosa, Jose Luis
AU  -  Alvarez-de-Toledo, Guillermo
AU  - Rodriguez-Moreno, Antonio
AU  - Armengol, Jose A
PY  - 2020
DO  - 10.3389/fnana.2020.592797
SN  - 1662-5129
UR  - http://hdl.handle.net/10668/16804
T2  - Frontiers in neuroanatomy
AB  - Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death by extensive autophagy. Our...
LA  - en
PB  - Frontiers Research Foundation
KW  - LTP
KW  - autophagy
KW  - dendritic spines
KW  - glutamatergic input
KW  - hippocampus
KW  - synapses
KW  - Purkinje Cells
KW  - CA1 Region, Hippocampal
KW  - CA3 Region, Hippocampal
KW  - Cerebellar Ataxia
KW  - Intellectual Disability
KW  - Morris Water Maze Test
KW  - Immunohistochemistry
KW  - Pyramidal Cells
KW  - Motor Neurons
KW  - Neocortex
KW  - Amygdala
TI  - HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory.
TY  - research article
VL  - 14
ER  -