RT Journal Article
T1 Antimicrobial Resistance Profiles of Adherent Invasive Escherichia coli Show Increased Resistance to β-Lactams.
A1 Martinez-Medina, Margarita
A1 Strozzi, Francesco
A1 Castillo, Belén Ruiz Del
A1 Serrano-Morillas, Natalia
A1 Bustins, Nuria Ferrer
A1 Martínez-Martínez, Luis
K1 AmpC β-lactamase
K1 Crohn’s disease
K1 adherent invasive Escherichia coli
K1 antimicrobial resistance
K1 β-lactams
AB The adherent invasive Escherichia coli (AIEC) pathotype has been associated with the aetiology of Crohn's disease (CD). Scarce reports have shown the antimicrobial resistance (AMR) profiles of AIEC. Despite antibiotics not being recommended to treat CD, antimicrobial therapy could be useful in stratified patients, such as AIEC carriers. We examined the antimicrobial resistance profiles of AIEC strains to identify which therapies could be effective or confer a risk for such patients. Phenotypic resistance to 30 antimicrobials was tested according to CLSI standards. AIEC (n = 22) and non-pathogenic E. coli (non-AIEC) strains (n = 37) isolated from the gut mucosa of 31 CD patients and 18 controls were studied. De novo genome sequencing was carried out for 39 of the 59 strains, and AMR genes were searched using the DeepARG database in these genomes and 33 additional AIEC publicly available genomes. The strains isolated from CD and controls showed similar phenotypic AMR profiles. The genomic analysis did not reveal an increased prevalence of AMR genes. However, AIEC strains were more frequently resistant to β-lactams than non-AIEC strains (11 AIEC (50%) and 5 non-AIEC (22%) strains were resistant to at least one β-lactam; p
SN 2079-6382
YR 2020
FD 2020-05-13
LK https://hdl.handle.net/10668/28027
UL https://hdl.handle.net/10668/28027
LA en
DS RISalud
RD Apr 12, 2025