RT Journal Article
T1 Stem/progenitor cells in normal physiology and disease of the pancreas.
A1 Alvarez Fallas, Mario Enrique
A1 Pedraza-Arevalo, Sergio
A1 Cujba, Ana-Maria
A1 Manea, Teodora
A1 Lambert, Christopher
A1 Morrugares, Rosario
A1 Sancho, Rocio
K1 Cell fate decisions
K1 Pancreas progenitors
K1 Stem cells
K1 scRNA-seq
AB Though embryonic pancreas progenitors are well characterised, the existence of stem/progenitor cells in the postnatal mammalian pancreas has been long debated, mainly due to contradicting results on regeneration after injury or disease in mice. Despite these controversies, sequencing advancements combined with lineage tracing and organoid technologies indicate that homeostatic and trigger-induced regenerative responses in mice could occur. The presence of putative progenitor cells in the adult pancreas has been proposed during homeostasis and upon different stress challenges such as inflammation, tissue damage and oncogenic stress. More recently, single cell transcriptomics has revealed a remarkable heterogeneity in all pancreas cell types, with some cells showing the signature of potential progenitors. In this review we provide an overview on embryonic and putative adult pancreas progenitors in homeostasis and disease, with special emphasis on in vitro culture systems and scRNA-seq technology as tools to address the progenitor nature of different pancreatic cells.
YR 2021
FD 2021-09-20
LK https://hdl.handle.net/10668/25320
UL https://hdl.handle.net/10668/25320
LA en
DS RISalud
RD Apr 5, 2025