RT Journal Article T1 Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease. A1 Frejo, Lidia A1 Gallego-Martinez, Alvaro A1 Requena, Teresa A1 Martin-Sanz, Eduardo A1 Amor-Dorado, Juan Carlos A1 Soto-Varela, Andres A1 Santos-Perez, Sofia A1 Espinosa-Sanchez, Juan Manuel A1 Batuecas-Caletrio, Angel A1 Aran, Ismael A1 Fraile, Jesus A1 Rossi-Izquierdo, Marcos A1 Lopez-Escamez, Jose Antonio AB Epidemiological studies have found a higher prevalence of allergic symptoms and positive prick tests in patients with Meniere's disease (MD); however the effect of allergenic extracts in MD has not been established. Thus, this study aims to determine the effect of Aspergillus and Penicillium stimulation in cytokine release and gene expression profile in MD. Patients with MD showed higher basal levels of IL-1β, IL-1RA, IL-6 and TNF-α when compared to healthy controls. We observed that IL-1β levels had a bimodal distribution suggesting two different subgroups of patients, with low and high basal levels of cytokines. Gene expression profile in peripheral blood mononuclear cells (PBMC) showed significant differences in patients with high and low basal levels of IL-1β. We found that both mold extracts triggered a significant release of TNF-α in MD patients, which were not found in controls. Moreover, after mold stimulation, MD patients showed a different gene expression profile in PBMC, according to the basal levels of IL-1β. The results indicate that a subset of MD patients have higher basal levels of proinflammatory cytokines and the exposure to Aspergillus and Penicillium extracts may trigger additional TNF-α release and contribute to exacerbate inflammation. YR 2018 FD 2018-04-13 LK http://hdl.handle.net/10668/12347 UL http://hdl.handle.net/10668/12347 LA en DS RISalud RD Apr 7, 2025