RT Journal Article
T1 Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project
A1 Zavala-Crichton, Juan Pablo
A1 Esteban-Cornejo, Irene
A1 Solis-Urra, Patricio
A1 Mora-Gonzalez, José
A1 Cadenas-Sanchez, Cristina
A1 Rodriguez-Ayllon, María
A1 Migueles, Jairo H.
A1 Molina-Garcia, Pablo
A1 Verdejo-Roman, Juan
A1 Kramer, Arthur F.
A1 Hillman, Charles H.
A1 Erickson, Kirk I.
A1 Catena, Andrés
A1 Ortega, Francisco B.
K1 Sedentariness
K1 TV viewing
K1 Magnetic resonance imaging
K1 Brain
K1 Cognition
K1 Childhood
K1 Obesity
K1 Sedentary behavior
K1 Imagen por resonancia magnética
K1 Encéfalo
K1 Cognición
K1 Obesidad
K1 Conducta sedentaria
AB We investigated the associations of di_erent sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (_ ranging 􀀀0.314 to 􀀀0.489 and cluster size 106 to 323 voxels; p < 0.001), playing video games in three brain regions (_ ranging 􀀀0.391 to 􀀀0.359, and cluster size 96 to 461 voxels; p < 0.001) and total sedentary time in two brain regions (_ ranging 􀀀0.341 to 􀀀0.352, and cluster size 897 to 2455 voxels; p < 0.001). No brain regions showed a significant positive association (all p > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.
PB MDPI
YR 2020
FD 2020-04-12
LK http://hdl.handle.net/10668/4124
UL http://hdl.handle.net/10668/4124
LA en
NO Zavala-Crichton JP, Esteban-Cornejo I, Solis-Urra P, Mora-Gonzalez J, Cadenas-Sanchez C, Rodriguez-Ayllon M, et al. Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project. J Clin Med. 2020 Apr 12;9(4):1101
DS RISalud
RD Apr 19, 2025