RT Journal Article
T1 The Leading Role of Peptide Tyrosine Tyrosine in Glycemic Control After Roux-en-Y Gastric Bypass in Rats.
A1 Camacho-Ramírez, Alonso
A1 Prada-Oliveira, J Arturo
A1 Ribelles-García, Antonio
A1 Almorza-Gomar, David
A1 Pérez-Arana, Gonzalo M
K1 Bariatric surgery
K1 Enteroinsular axis
K1 Glucagon-like peptide-1
K1 Insulin secretion
K1 Peptide hormones
K1 Peptide tyrosine tyrosine
AB Roux-en-Y gastric bypass (RYGB) is one of the most effective surgical therapies for the rapid resolution of type 2 diabetes. However, the mechanisms underlying the entero-hormonal response after surgery and the role of peptide tyrosine tyrosine (PYY) in the restoration of normoglycemia are still not clear. We reproduced the RYGB technique in Wistar and Goto-Kakizaki rats and performed serum hormonal, histological, and hormonal-infusion test. Using the diabetic Goto-Kakizaki (GK) rat model, we demonstrated that PYY plasma levels showed a remarkable peak approximately 30 min earlier than GLP-1 or GIP after mixed-meal administration in RYGB-operated rats with PYY. The GLP-1 and GIP areas under the curve (AUCs) increased after RYGB in GK rats. Additionally, the findings suggested that PYY (3-36) infusion led to increased GLP-1 and GIP plasma levels close to those obtained after a meal. Finally, the number of GLP-1-positive cells appeared to increase in the three segments of the small intestine in GK-RYGB-operated rats beyond the early presence of nutrient stimulation in the ileum. Nevertheless, PYY-positive cell numbers appeared to increase only in the ileum. At least in rats, these data demonstrate an earlier essential role for PYY in gut hormone regulation after RYGB. We understand that PYY contributes to GLP-1 and GIP release and there must be the existence of enteroendocrine communication routes between the distal and proximal small intestine.
YR 2020
FD 2020
LK http://hdl.handle.net/10668/14657
UL http://hdl.handle.net/10668/14657
LA en
DS RISalud
RD Apr 11, 2025