RT Journal Article
T1 Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain).
A1 García-Pérez, Javier
A1 Fernández de Larrea-Baz, Nerea
A1 Lope, Virginia
A1 Molina, Antonio J
A1 O'Callaghan-Gordo, Cristina
A1 Alonso, María Henar
A1 Rodríguez-Suárez, Marta María
A1 Mirón-Pozo, Benito
A1 Alguacil, Juan
A1 Gómez-Acebo, Inés
A1 Ascunce, Nieves
A1 Vanaclocha-Espi, Mercedes
A1 Amiano, Pilar
A1 Chirlaque, María Dolores
A1 Simó, Vicente
A1 Jiménez-Moleón, José J
A1 Tardón, Adonina
A1 Moreno, Víctor
A1 Castaño-Vinyals, Gemma
A1 Martín, Vicente
A1 Aragonés, Nuria
A1 Pérez-Gómez, Beatriz
A1 Kogevinas, Manolis
A1 Pollán, Marina
K1 Case-control study
K1 Colorectal cancer
K1 Industrial pollution
K1 MCC-Spain
K1 Residential proximity
AB Colorectal cancer is the third most frequent tumor in males and the second in females worldwide. In Spain, it is an important and growing health problem, and epidemiologic research focused on potential risk factors, such as environmental exposures, is necessary. To analyze the association between colorectal cancer risk and residential proximity to industries, according to pollution discharge route, industrial groups, categories of carcinogens and other toxic substances, and specific pollutants released, in the context of a population-based multicase-control study of incident cancer carried out in Spain (MCC-Spain). MCC-Spain included 557 colorectal cancer cases and 2948 controls in 11 provinces, frequency matched by sex, age, and region of residence. Distances were computed from subjects' residences to each of the 134 industries located in the study area. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95%CIs) for categories of distance (from 1 km to 3 km) to industrial facilities, adjusting for matching variables and other confounders. Excess risk (OR; 95%CI) of colorectal cancer was detected near industries overall for all distances analyzed, from 1 km (2.03; 1.44-2.87) to 3 km (1.26; 1.00-1.59). In general, industries releasing pollutants to air showed higher excess risks than facilities releasing pollution to water. By industrial sector, excess risk (OR; 95%CI) was found near (≤3 km) production of metals (2.66; 1.77-4.00), surface treatment of metals (1.48; 1.08-2.02), glass and mineral fibers (2.06; 1.39-3.07), organic chemical industry (4.80; 3.20-7.20), inorganic chemical industry (6.74; 4.38-10.36), food/beverage sector (3.34; 2.38-4.68), and surface treatment using organic solvents (6.16; 4.06-9.36). By pollutants, the main excess risks (OR; 95%CI) were found near (≤3 km) industries releasing nonylphenol (9.19; 5.91-14.28), antimony (5.30; 3.45-8.15), naphthalene (3.11; 2.16-4.49), organotin compounds (2.64; 1.76-3.98), manganese (2.53; 1.63-3.93), dichloromethane (2.52; 1.74-3.66), and vanadium (2.49; 1.59-3.91). Our results support the hypothesis that residing in the proximity of industries may be a risk factor for colorectal cancer.
YR 2020
FD 2020-08-19
LK http://hdl.handle.net/10668/16133
UL http://hdl.handle.net/10668/16133
LA en
DS RISalud
RD Apr 5, 2025