RT Journal Article
T1 The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients
A1 Villar, Sara
A1 Ariceta, Benat
A1 Agirre, Xabier
A1 Urribarri, Aura Daniela
A1 Ayala, Rosa
A1 Martinez-Cuadron, David
A1 Miguel Bergua, Juan
A1 Vives, Susana
A1 Algarra, Lorenzo
A1 Tormo, Mar
A1 Martinez, Pilar
A1 Serrano, Josefina
A1 Simoes, Catia
A1 Herrera, Pilar
A1 Jose Calasanz, Maria
A1 Alfonso-Pierola, Ana
A1 Paiva, Bruno
A1 Martinez-Lopez, Joaquin
A1 San Miguel, Jesus F.
A1 Prosper, Felipe
A1 Montesinos, Pau
K1 B7-h3
K1 Smar1
K1 Expression
K1 P53
K1 Classification
K1 Progression
K1 Activation
AB Acute myeloid leukemia (AML) in the elderly remains a clinical challenge, with a five-year overall survival rate below 10%. The current ELN 2017 genetic risk classification considers cytogenetic and mutational characteristics to stratify fit AML patients into different prognostic groups. However, this classification is not validated for elderly patients treated with a non-intensive approach, and its performance may be suboptimal in this context. Indeed, the transcriptomic landscape of AML in the elderly has been less explored and it might help stratify this group of patients. In the current study, we analyzed the transcriptome of 224 AML patients > 65 years-old at diagnosis treated in the Spanish PETHEMA-FLUGAZA clinical trial in order to identify new prognostic biomarkers in this population. We identified a specific transcriptomic signature for high-risk patients with mutated TP53 or complex karyotype, revealing that low expression of B7H3 gene with high expression of BANP gene identifies a subset of high-risk AML patients surviving more than 12 months. This result was further validated in the BEAT AML cohort. This unique signature highlights the potential of transcriptomics to identify prognostic biomarkers in in elderly AML.
PB Frontiers Research Foundation
SN 2234-943X
YR 2022
FD 2022-11-02
LK http://hdl.handle.net/10668/20688
UL http://hdl.handle.net/10668/20688
LA en
NO Villar S, Ariceta B, Agirre X, Urribarri AD, Ayala R, Martínez-Cuadrón D, et al. The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients. Front Oncol. 2022 Nov 24;12:1054458
DS RISalud
RD Apr 12, 2025