RT Conference Proceedings
T1 Gender differences in cardiovascular risk factors in HIV infected patients on antiretroviral therapy: Data from the Spanish Coronator study.
A1 Santos, J
A1 Olalla, J
A1 Pérez-Elías, M
A1 Miralles, C
A1 Lozano, F
A1 Iribarren, J
A1 Masiá, M
A1 Domingo, P
A1 Bernardino, J
A1 Estrada, V
K1 Infecciones por VIH
K1 Obesidad Abdominal
K1 Síndrome de Inmunodeficiencia Adquirida
K1 Antígenos CD4
K1 HDL-Colesterol
K1 Quimioterapia
AB Purpose: HIV-infected patients present an increased cardiovascular risk (CVR) of multifactorial origin, usually lower in women than in men. Information by gender about prevalence of modifiable risk factors is scarce. Methods: Coronator is a cross-sectional survey of a representative sample of HIV-infected patients on ART within 10 hospitals across Spain in 2011. Variables include sociodemographics, CVR factors and 10-year CV disease risk estimation (Regicor: Framingham score adapted to the Spanish population). Results: We included 860 patients (76.3% male) with no history of CVD. Median age 45.6 years; 84.1% were Spaniards; 29.9% women were IDUs. Median time since HIV diagnosis for men and women was 10 and 13 years (p=0.001), 28% had an AIDS diagnosis. Median CD4 cell count was 596 cells/mm3, 88% had undetectable viral load. Median time on ART was 91 and 108 months (p=0.017). There was a family history of early CVD in 113 men (17.9%) and 41 women (20.6%). Classical CVR factors are described in the table. Median (IQR) Regicor Score was 3% (2-5) for men and 2% (1-3) for women (p=0.000), and the proportion of subjects with mid-high risk (>5%) was 26.1% for men and 9.4% for women (p=0.000). Conclusions: In this population of HIV-infected patients, women have lower cardiovascular risk than men, partly due to higher levels of HDL cholesterol. Of note is the high frequency of smoking, abdominal obesity and sedentary lifestyle in our population. (Table Presented).
PB BioMed Central
YR 2012
FD 2012-11-11
LK http://hdl.handle.net/10668/1418
UL http://hdl.handle.net/10668/1418
LA en
NO Santos J., Olalla J., Pérez Elías M., Miralles C., Lozano F., Iribarren J. et al. Gender differences in cardiovascular risk factors in HIV infected patients on antiretroviral therapy: Data from the Spanish Coronator study. Journal of the International AIDS Society. 2012;15(Suppl. 4):18131.
NO Abstract of the Eleventh International Congress on Drug Therapy in HIV Infection
DS RISalud
RD Apr 15, 2025