RT Journal Article
T1 Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis.
A1 Papais-Alvarenga, Marcos
A1 Ferreira-do-Carmo, Luciana
A1 Ferreira-Vasconcelos, Claudia Cristina
A1 Papais-Alvarenga, Marina
A1 Alvarenga-Filho, Helcio
A1 Alves-de-Melo-Bento, Cleonice
A1 Antao-Paiva, Carmen Lucia
A1 Leyva-Fernandez, Laura
A1 Fernandez, Oscar
A1 Papais-Alvarenga, Regina Maria
K1 Autoimmune Diseases
K1 Ethnicity
K1 Meta-Analysis
K1 Demyelinating Diseases
K1 Systematic Review
AB Neuromyelitis Optica and Multiple Sclerosis are idiopathic inflammatory demyelinating diseases of the central nervous system that currently are considered distinct autoimmune diseases, so differences in genetic susceptibility would be expected. This study aimed to investigate the HLA association with Neuromyelitis Optica by a systematic review with meta-analysis. The STROBE instrument guided research paper assessments. Thirteen papers published between 2009 and 2020 were eligible. 568 Neuromyelitis Optica patients, 41.4% Asians, 32.4% Latin Americans and 26.2% Europeans were analyzed. Only alleles of the DRB1 locus were genotyped in all studies. Neuromyelitis Optica patients have 2.46 more chances of having the DRB1*03 allelic group than controls. Ethnicity can influence genetic susceptibility. The main HLA association with Neuromyelitis Optica was the DRB1*03:01 allele in Western populations and with the DPB1*05:01 allele in Asia. Differences in the Multiple Sclerosis and Neuromyelitis Optica genetic susceptibility was confirmed in Afro descendants. The DRB1*03 allelic group associated with Neuromyelitis Optica has also been described in other systemic autoimmune diseases.
PB Nature Publishing Group
YR 2021
FD 2021-01-08
LK http://hdl.handle.net/10668/16944
UL http://hdl.handle.net/10668/16944
LA en
NO Alvarenga MP, do Carmo LF, Vasconcelos CCF, Alvarenga MP, Alvarenga-Filho H, de Melo Bento CA, et al. Neuromyelitis optica is an HLA associated disease different from Multiple Sclerosis: a systematic review with meta-analysis. Sci Rep. 2021 Jan 8;11(1):152
DS RISalud
RD Aug 5, 2025