TY  - JOUR
AU  - Sánchez-Maldonado, Jose Manuel
AU  - Cáliz, Rafael
AU  - López-Nevot, Miguel Ángel
AU  - Cabrera-Serrano, Antonio José
AU  - Moñiz-Díez, Ana
AU  - Canhão, Helena
AU  - Ter Horst, Rob
AU  - Quartuccio, Luca
AU  - Sorensen, Signe B.
AU  - Glintborg, Bente
AU  - Hetland, Merete L.
AU  - Filipescu, Ileana
AU  - Pérez-Pampin, Eva
AU  - Conesa-Zamora, Pablo
AU  - Swierkot, Jerzy
AU  - den Broeder, Alfons A.
AU  - De Vita, Salvatore
AU  - Petersen, Eva Rabing Brix
AU  - Li, Yang
AU  - Ferrer, Miguel A.
AU  - Escudero, Alejandro
AU  - Netea, Mihai G.
AU  - Coenen, Marieke J. H.
AU  - Andersen, Vibeke
AU  - Fonseca, João E.
AU  - Jurado, Manuel
AU  - Bogunia-Kubik, Katarzyna
AU  - Collantes, Eduardo
AU  - Sainz, Juan
PY  - 2021
DO  - 10.3389/fimmu.2021.672255
UR  - http://hdl.handle.net/10668/4535
T2  - Frontiers in Immunology
AB  - We aimed to validate the association of 28 GWAS-identified genetic variants for response to TNF inhibitors (TNFi) in a discovery cohort of 1361 rheumatoid arthritis (RA) patients monitored in routine care and ascertained through the REPAIR consortium...
LA  - en
PB  - Frontiers
KW  - GWAS
KW  - Genetic variant
KW  - Rheumatoid arthritis
KW  - Drug response
KW  - TNF inhibitors
KW  - Rheumatoid factor
KW  - Escherichia coli
KW  - Polymorphism, single nucleotide
KW  - Alleles
KW  - Variantes farmacogenómicas
KW  - Artritis reumatoide
KW  - Biomarcadores farmacológicos
KW  - Inhibidores del factor de necrosis tumoral
KW  - Factor reumatoide
KW  - Polimorfismo de nucleótido simple
KW  - Alelos
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles
KW  - Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, Pharmacological
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Linkage::Linkage Disequilibrium
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Molecular Epidemiology::Genome-Wide Association Study
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Rheumatoid Factor
KW  - Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6
KW  - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries
TI  - Validation of GWAS-Identified Variants for Anti-TNF Drug Response in Rheumatoid Arthritis: A Meta-Analysis of Two Large Cohorts
TY  - research article
ER  -