RT Journal Article
T1 Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort.
A1 Peters, Susan
A1 Broberg, Karin
A1 Gallo, Valentina
A1 Levi, Michael
A1 Kippler, Maria
A1 Vineis, Paolo
A1 Veldink, Jan
A1 van den Berg, Leonard
A1 Middleton, Lefkos
A1 Travis, Ruth C
A1 Bergmann, Manuela M
A1 Palli, Domenico
A1 Grioni, Sara
A1 Tumino, Rosario
A1 Elbaz, Alexis
A1 Vlaar, Tim
A1 Mancini, Francesca
A1 Kühn, Tilman
A1 Katzke, Verena
A1 Agudo, Antonio
A1 Goñi, Fernando
A1 Gómez, Jesús-Humberto
A1 Rodríguez-Barranco, Miguel
A1 Merino, Susana
A1 Barricarte, Aurelio
A1 Trichopoulou, Antonia
A1 Jenab, Mazda
A1 Weiderpass, Elisabete
A1 Vermeulen, Roel
AB Metals have been suggested as a risk factor for amyotrophic lateral sclerosis (ALS), but only retrospective studies are available to date. We compared metal levels in prospectively collected blood samples from ALS patients and controls, to explore whether metals are associated with ALS mortality. A nested ALS case-control study was conducted within the prospective EPIC (European Prospective Investigation into Cancer and Nutrition) cohort. Cases were identified through death certificates. We analyzed metal levels in erythrocyte samples obtained at recruitment, as a biomarker for metal exposure from any source. Arsenic, cadmium, copper, lead, manganese, mercury, selenium, and zinc concentrations were measured by inductively coupled plasma-mass spectrometry. To estimate ALS risk, we applied conditional logistic regression models. The study population comprised 107 cases (65% female) and 319 controls matched for age, sex, and study center. Median time between blood collection and ALS death was 8 years (range = 1-15). Comparing the highest with the lowest tertile, cadmium (odds ratio [OR] = 2.04, 95% confidence interval [CI] = 1.08-3.87) and lead (OR = 1.89, 95% CI = 0.97-3.67) concentrations suggest associations with increased ALS risk. Zinc was associated with a decreased risk (OR = 0.50, 95% CI = 0.27-0.94). Associations for cadmium and lead remained when limiting analyses to noncurrent smokers. This is the first study to compare metal levels before disease onset, minimizing reverse causation. The observed associations suggest that cadmium, lead, and zinc may play a role in ALS etiology. Cadmium and lead possibly act as intermediates on the pathway from smoking to ALS. ANN NEUROL 20209999:n/a-n/a.
YR 2020
FD 2020-11-06
LK http://hdl.handle.net/10668/16438
UL http://hdl.handle.net/10668/16438
LA en
DS RISalud
RD Apr 11, 2025