%0 Journal Article
%A Lemus-Conejo, Ana
%A Grao-Cruces, Elena
%A Toscano, Rocio
%A Varela, Lourdes M
%A Claro, Carmen
%A Pedroche, Justo
%A Millan, Francisco
%A Millan-Linares, Maria C
%A Montserrat-de la Paz, Sergio
%T A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice.
%D 2020
%U http://hdl.handle.net/10668/15343
%X Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg-1 day-1 or 1 mg kg-1 day-1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways.
%K Animals
%K Diet, High-Fat
%K Functional Food
%K Mice, Inbred C57BL
%K Plant Extracts
%K Random Allocation
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