RT Journal Article
T1 mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol.
A1 Gonzalez-Garcia, Ismael
A1 Martinez de Morentin, Pablo B
A1 Estevez-Salguero, Anxela
A1 Contreras, Cristina
A1 Romero-Pico, Amparo
A1 Fernø, Johan
A1 Nogueiras, Ruben
A1 Dieguez, Carlos
A1 Tena-Sempere, Manuel
A1 Tovar, Sulay
A1 Lopez, Miguel
K1 Estradiol
K1 Food intake
K1 Hypothalamus
K1 mTOR
K1 Obesity
AB Current evidence suggests that estradiol (E2), the main ovarian steroid, modulates energy balance by regulating both feeding and energy expenditure at the central level, through the energy sensor AMP-activated protein kinase (AMPK). We hypothesized that the hypothalamic mechanistic target of rapamycin (mTOR) pathway, a well-established nutrient sensor and modulator of appetite and puberty, could also mediate the anorectic effect of E2. Our data showed that ovariectomy (OVX) elicited a marked downregulation of the mTOR signaling in the arcuate nucleus of the hypothalamus (ARC), an effect that was reversed by either E2 replacement or central estrogen receptor alpha (ERα) agonism. The significance of this molecular signaling was given by the genetic inactivation of S6 kinase B1 (S6K1, a key downstream mTOR effector) in the ARC, which prevented the E2-induced hypophagia and weight loss. Overall, these data indicate that E2 induces hypophagia through modulation of mTOR pathway in the ARC.
PB BioScientifica
YR 2018
FD 2018-06-18
LK http://hdl.handle.net/10668/12608
UL http://hdl.handle.net/10668/12608
LA en
NO González-García I, Martínez de Morentin PB, Estévez-Salguero Á, Contreras C, Romero-Picó A, Fernø J, et al. mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol. J Endocrinol. 2018 Sep;238(3):177-186
DS RISalud
RD Apr 10, 2025