RT Journal Article
T1 Etiopathogenesis of ovarian cancer. An inflamm-aging entity?
A1 Sánchez-Prieto, Manuel
A1 Sánchez-Borrego, Rafael
A1 Lubián-López, Daniel Maria
A1 Pérez-López, Faustino R
K1 Aging
K1 Carcinogenesis
K1 Inflammaging
K1 Inflammation
K1 Ovarian cancer
AB Ovarian cancer is one of the most common gynecologic cancers and has the highest mortality rate. The risk/protective factors of ovarian cancer suggest that its etiology is multifactorial. Several factors are involved in age-related increases in carcinogenesis, including the accumulation of senescent cells, inflammaging (a chronic inflammatory state that persists in the elderly), and immunosenescence (aging of the immune system) changes associated with poor immune surveillance. At sites of inflammation, exposure to high levels of inflammatory mediators, such as reactive oxygen species, cytokines, prostaglandins, and growth factors, contributes to increased cell division and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the proinflammatory tumor microenvironment contributes to ovarian cancer metastasis and chemoresistance. This narrative review of the literature was carried out to delineate the possible role of inflammaging in the etiopathogenesis of ovarian cancer development. We discuss the current carcinogenic hypotheses, sites of origin, and etiological factors of ovarian cancer. Treatment of inflammation may represent an attractive strategy for both the prevention and therapy of ovarian cancer.
SN 2352-5789
YR 2022
FD 2022-06-11
LK http://hdl.handle.net/10668/22254
UL http://hdl.handle.net/10668/22254
LA en
DS RISalud
RD Apr 11, 2025