RT Journal Article
T1 The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent.
A1 Argente-Arizon, Pilar
A1 Diaz, Francisca
A1 Ros, Purificacion
A1 Barrios, Vicente
A1 Tena-Sempere, Manuel
A1 Garcia-Segura, Luis Miguel
A1 Argente, Jesus
A1 Chowen, Julie A
K1 Inflammation Mediators
K1 Microglia
K1 Nerve Tissue Proteins
K1 Rats, Wistar
K1 Sex Characteristics
K1 Signal Transduction
K1 Weight Gain
AB Astrocytes participate in both physiological and pathophysiological responses to metabolic and nutrient signals. Although most studies have focused on the astrocytic response to weight gain due to high-fat/high-carbohydrate intake, surplus intake of a balanced diet also induces excess weight gain. We have accessed the effects of neonatal overnutrition, which has both age- and sex-dependent effects on weight gain, on hypothalamic inflammation/gliosis. Although both male and female Wistar rats accumulate excessive fat mass as early as postnatal day (PND) 10 with neonatal overnutrition, no increase in hypothalamic cytokine levels, markers of astrocytes or microglia, or inflammatory signaling pathways were observed. At PND 50, no effect of neonatal overnutriton was found in either sex, whereas at PND 150, males again weighed significantly more than their controls, and this was coincident with an increase in markers of inflammation and astrogliosis in the hypothalamus. Circulating triglycerides and free fatty acids were also elevated in these males, but not in females or in either sex at PND 10. Thus, the effects of fatty acids and estrogens on astrocytes in vitro were analyzed. Our results indicate that changes in circulating fatty acid levels may be involved in the induction of hypothalamic inflammation/gliosis in excess weight gain, even on a normal diet, and that estrogens could participate in the protection of females from these processes. In conclusion, the interaction of developmental influences, dietary composition, age, and sex determines the central inflammatory response and the associated long-term outcomes of excess weight gain.
PB Oxford University Press
YR 2017
FD 2017-10-20
LK http://hdl.handle.net/10668/11739
UL http://hdl.handle.net/10668/11739
LA en
NO Argente-Arizón P, Díaz F, Ros P, Barrios V, Tena-Sempere M, García-Segura LM, et al. The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent. Endocrinology. 2018 Jan 1;159(1):368-387
NO This work was supported by grants from the Spanish Ministry of Science and Innovation (BFU2014-51836-C2-2 to J.A.C. and BFU2014-51836-C2-1 to L.M.G.-S.), Fondo de Investigación Sanitaria (PI-1302195 and PI16/00485to J.A., Centro de Investigación Biomédica en Red: Fisiopatología de la Obesidad y Nutrici´on to J.A. and M.T.-S., and Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable to L.M.G.-S.), and Fondo Europeo de Desarrollo Regional.
DS RISalud
RD Apr 9, 2025