RT Journal Article T1 Usefulness of the Hybrid RFR-FFR Approach: Results of a Prospective and Multicenter Analysis of Diagnostic Agreement between RFR and FFR-The RECOPA (REsting Full-Cycle Ratio Comparation versus Fractional Flow Reserve (A Prospective Validation)) Study A1 Casanova-Sandoval, Juan A1 Fernandez-Rodriguez, Diego A1 Otaegui, Imanol A1 Gil Jimenez, Teresa A1 Rodriguez-Esteban, Marcos A1 Rivera, Kristian A1 Torres-Saura, Francisco A1 Jimenez Diaz, Victor A1 Ocaranza-Sanchez, Raymundo A1 Peral Disdier, Vicente A1 Sanchez-Elvira, Guillermo A1 Worner, Fernando K1 Wave-free ratio K1 Invasive physiological indexes K1 Artery stenosis severity K1 Pressure measurements K1 Blood-flow K1 Coronary AB Background. The resting full-cycle ratio (RFR) is a novel resting index which in contrast to the gold standard (fractional flow reserve (FFR)) does not require maximum hyperemia induction. The objectives of this study were to evaluate the agreement between RFR and FFR with the currently recommended thresholds and to design a hybrid RFR-FFR ischemia detection strategy, allowing a reduction of coronary vasodilator use. Materials and Methods. Patients subjected to invasive physiological study in 9 Spanish centers were prospectively recruited between April 2019 and March 2020. Sensitivity and specificity studies were made to assess diagnostic accuracy between the recommended levels of RFR PB Wiley-hindawi SN 0896-4327 YR 2021 FD 2021-03-31 LK http://hdl.handle.net/10668/19078 UL http://hdl.handle.net/10668/19078 LA en DS RISalud RD Apr 9, 2025