RT Journal Article
T1 Postprandial Hyperlipidemia: Association with Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis.
A1 Mena-Vazquez, Natalia
A1 Redondo-Rodriguez, Rocio
A1 Rioja, Jose
A1 Jimenez-Nuñez, Francisco Gabriel
A1 Manrique-Arija, Sara
A1 Lisbona-Montañez, Jose Manuel
A1 Cano-Garcia, Laura
A1 Rojas-Gimenez, Marta
A1 Ureña, Inmaculada
A1 Valdivielso, Pedro
A1 Fernandez-Nebro, Antonio
K1 Inflammation
K1 Postprandial lipemia
K1 Rheumatoid arthritis
K1 Subclinical atherosclerosis
K1 Triglycerides
AB To describe postprandial lipidemia in patients with rheumatoid arthritis (RA) and to analyze its association with subclinical atherosclerosis and inflammatory activity. Observational study of 80 cases of RA and 80 sex- and age-matched controls. We excluded individuals with dyslipidemia. Postprandial hyperlipidemia (PPHL) was defined as postprandial triglycerides >220 mg/dL and/or postprandial ApoB48 levels >75th percentile (>p75). Plasma lipids, cholesterol, triglycerides, ApoB48, and total ApoB were evaluated at baseline and after a meal. Other variables analyzed included subclinical atherosclerosis (defined as presence of carotid atheromatous plaque), inflammatory activity (disease activity score (DAS28-ESR)), cytokines, apolipoproteins, and physical activity. A multivariate analysis was performed to identify factors associated with PPHL in patients with RA. A total of 75 patients with RA and 67 healthy controls fulfilled the inclusion criteria. PPHL was more frequent in patients with RA than controls (No. (%), 29 (38.70) vs. 15 (22.40); p = 0.036), as was subclinical atherosclerosis (No. (%), 22 (30.10) vs. 10 (14.90); p = 0.032). PPHL in patients with RA was associated with subclinical atherosclerosis (OR (95% CI) 4.69 (1.09-12.11); p = 0.037), TNF-α (OR (95% CI) 2.00 (1.00-3.98); p = 0.048), high-sensitivity C-reactive protein (OR (95% CI) 1.10 (1.01-1.19); p = 0.027), and baseline triglycerides (OR (95% CI) 1.02 (1.00-1.04); p = 0.049). PPHL was more frequent in patients with RA than in controls. PPHL in patients with RA was associated with inflammation and subclinical atherosclerosis.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-01-06
LK http://hdl.handle.net/10668/20813
UL http://hdl.handle.net/10668/20813
LA en
NO Mena-Vázquez N, Redondo-Rodríguez R, Rioja J, Jimenez-Nuñez FG, Manrique-Arija S, Lisbona-Montañez JM, et al. Postprandial Hyperlipidemia: Association with Inflammation and Subclinical Atherosclerosis in Patients with Rheumatoid Arthritis. Biomedicines. 2022 Jan 8;10(1):133
DS RISalud
RD Apr 18, 2025