TY - JOUR AU - Casado, Concepcion AU - Galvez, Cristina AU - Pernas, Maria AU - Tarancon-Diez, Laura AU - Rodriguez, Carmen AU - Sanchez-Merino, Víctor AU - Vera, Mar AU - Olivares, Isabel AU - De Pablo-Bernal, Rebeca AU - Merino-Mansilla, Alberto AU - Del Romero, Jorge AU - Lorenzo-Redondo, Ramon AU - Ruiz-Mateos, Ezequiel AU - Salgado, María AU - Martinez-Picado, Javier AU - Lopez-Galindez, Cecilio PY - 2020 DO - 10.1038/s41598-020-58696-y UR - http://hdl.handle.net/10668/4324 T2 - Scientific Reports AB - Elite controllers (EC) represent a small subset of HIV-1-infected people that spontaneously control viral replication. However, natural virological suppression and absence of immune dysfunction are not always long-term sustained. We define exceptional... LA - en PB - Springer Nature KW - Disease progression KW - HIV-1 KW - Spontaneous cure KW - DNA KW - Viral load KW - Elite controllers, HIV KW - Viruses KW - Progresión de la enfermedad KW - VIH-1 KW - ADN KW - Virus KW - Carga viral KW - VIH no-progresivos KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections KW - Medical Subject Headings::Organisms::Viruses::RNA Viruses::Retroviridae::Lentivirus::Lentiviruses, Primate::HIV::HIV-1 KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression::Remission, Spontaneous KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Microbiological Techniques::Viral Load KW - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiological Processes::Virus Physiological Processes::Virus Replication KW - Medical Subject Headings::Persons::Persons::Patients::Survivors::HIV Long-Term Survivors KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological KW - Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD4-Positive T-Lymphocytes KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Microbial::Genes, Viral::Genes, env KW - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity KW - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA TI - Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure TY - research article ER -