RT Journal Article
T1 Severe acute hepatitis and cold agglutinin-related hemolytic anemia secondary to prime infection with Epstein-Barr virus.
A1 Ontanilla Clavijo, Guillermo
A1 Praena Segovia, Julia
A1 Giráldez Gallego, Álvaro
A1 Cordero Matía, María Elisa
A1 Sousa Martín, José Manuel
AB Epstein-Barr virus, a member of the Herpesviridae family, is responsible for the infectious mononucleosis clinical syndrome, which mainly includes the pharyngitis, fever, and lymphadenopathy triad after incubation for 30-50 days. The liver is involved in 80-90% of patients in a self-limiting transient manner, with jaundice being much more uncommon (5%). From a hematological standpoint it may manifest aplastic anemia, neutropenia, and thrombocytopenia. We report a case of infectious mononucleosis that included severe acute hepatitis and was associated with severe hemolytic anemia secondary to cold agglutinins. After exclusion of other etiologies, and given the clinical suspicion of the above association, which was later confirmed by lab tests, empiric therapy was initiated with antiviral agents (aciclovir + valganciclovir) and corticoids, which resulted in a progressive clinical improvement until complete remission. Therefore, we believe that this case report will reinforce the clinical evidence in support of the above combined therapy for serious infectious mononucleosis as a step prior to liver transplantation.
SN 1130-0108
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11053
UL http://hdl.handle.net/10668/11053
LA en
DS RISalud
RD Apr 12, 2025