RT Journal Article
T1 Flavonoids in Inflammatory Bowel Disease: A Review.
A1 Vezza, Teresa
A1 Rodríguez-Nogales, Alba
A1 Algieri, Francesca
A1 Utrilla, Maria Pilar
A1 Rodriguez-Cabezas, Maria Elena
A1 Galvez, Julio
K1 barrier function
K1 eicosanoids
K1 flavonoids
K1 immunomodulatory properties
K1 inflammatory bowel disease
K1 oxidative stress
AB Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the intestine that compromises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their etiology is not completely understood, non-fully-efficient drugs have been developed and those that have shown effectiveness are not devoid of quite important adverse effects that impair their long-term use. In this regard, a growing body of evidence confirms the health benefits of flavonoids. Flavonoids are compounds with low molecular weight that are widely distributed throughout the vegetable kingdom, including in edible plants. They may be of great utility in conditions of acute or chronic intestinal inflammation through different mechanisms including protection against oxidative stress, and preservation of epithelial barrier function and immunomodulatory properties in the gut. In this review we have revised the main flavonoid classes that have been assessed in different experimental models of colitis as well as the proposed mechanisms that support their beneficial effects.
YR 2016
FD 2016-04-09
LK http://hdl.handle.net/10668/9990
UL http://hdl.handle.net/10668/9990
LA en
DS RISalud
RD Apr 12, 2025