RT Journal Article
T1 New 3-Hydroxyquinaldic Acid Derivatives from Cultures of the Marine Derived Actinomycete Streptomyces cyaneofuscatus M-157.
A1 Ortiz-López, Francisco Javier
A1 Alcalde, Elsa
A1 Sarmiento-Vizcaíno, Aida
A1 Díaz, Caridad
A1 Cautain, Bastien
A1 García, Luis A
A1 Blanco, Gloria
A1 Reyes, Fernando
K1 3-hydroxyquinaldic acid
K1 Cantabrian Sea
K1 Streptomyces cyaneofuscatus
K1 deep-sea actinobacteria
AB Fractionation of the bioactive extract of a culture of the marine derived actinomycete Streptomyces cyaneofuscatus M-157 led to the isolation of the known 3-hydroxyquinaldic acid (4), its amide (5) and three new derivatives (1⁻3) containing different amino acid residues. The structures of the new molecules (1⁻3), including their absolute configuration, were determined by the analysis of their ESI-TOF MS and one-dimensional (1D) and two-dimensional (2D) NMR spectra and advanced Marfey's analysis of their hydrolyzation products. Compound 3 spontaneously dimerized in solution to give the disulfide derivative 6. Unfortunately, none of the new compounds isolated confirmed the antimicrobial activity found in the bacterial extract, perhaps indicating that such antibacterial activity might be due to presence in the extract at the trace level of larger bioactive 3-hydroxyquinaldic acid derivatives from which compounds 1⁻3 are biosynthetic precursors. Cytotoxicity tests confirmed the moderate and weak IC50 values of 15.6 and 51.5 µM for compounds 5 and 1, respectively.
YR 2018
FD 2018-10-08
LK http://hdl.handle.net/10668/13044
UL http://hdl.handle.net/10668/13044
LA en
DS RISalud
RD Apr 6, 2025