RT Journal Article
T1 Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson´s disease within the EPIC4ND cohort.
A1 Gröninger, Mareike
A1 Sabin, Jara
A1 Kaaks, Rudolf
A1 Amiano, Pilar
A1 Aune, Dagfinn
A1 Castro, Natalia Cabrera
A1 Guevara, Marcela
A1 Hansen, Johnni
A1 Homann, Jan
A1 Masala, Giovanna
A1 Nicolas, Geneviève
A1 Peters, Susan
A1 Sacerdote, Carlotta
A1 Sánchez, María José
A1 De Magistris, Maria Santucci
A1 Sieri, Sabina
A1 Vermeulen, Roel
A1 Zhao, Yujia
A1 Lill, Christina M
A1 Katzke, Verena A
K1 Calcium
K1 Dairy
K1 EPIC
K1 Parkinson´s disease
K1 Vitamin D
AB Literature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 participants of the EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Crude and multivariable-adjusted Cox proportional hazards models were employed to examine potential associations between baseline dietary intake of dairy, calcium and vitamin D with incident PD risk. No relationship was observed between dairy consumption (HR 1.07, 95% CI 0.82-1.39), individual dairy products (milk: HR 0.95, 95% CI 0.73-1.23; yogurt: HR 1.03, 95% CI 0.82-1.29; cheese: HR 1.13, 95% CI 0.85-1.51), or vitamin D (HR 1.08, 95% CI 0.80-1.45) with PD risk. However, we observed a risk-increasing association with higher calcium intakes (HR 1.33, 95% CI 1.00-1.78, p for trend = 0.031), which was more pronounced in men (HR 1.50, 95% CI 1.00-2.25, p for trend = 0.044) and in ever smokers (HR 1.64, 95% CI 1.06-2.53, p for trend = 0.014). No compelling evidence was found for an association between dairy products or vitamin D intake and PD risk indicating a potentially limited relevance of dairy intake in PD risk than previously described. Our observations of a positive association between dietary calcium intake and PD risk in men and in ever smokers require further validation.
PB Kluwer Academic Publishers
SN 1573-7284
YR 2024
FD 2024-11
LK https://hdl.handle.net/10668/28483
UL https://hdl.handle.net/10668/28483
LA en
NO Gröninger M, Sabin J, Kaaks R, Amiano P, Aune D, Castro NC,  et al. Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson´s disease within the EPIC4ND cohort. Eur J Epidemiol. 2024 Nov;39(11):1251-1265.
DS RISalud
RD Apr 8, 2025