RT Journal Article
T1 Magnetic Resonance Enterography Cannot Replace Upper Endoscopy in Pediatric Crohn Disease: An Imagekids Sub-study.
A1 Church, Peter C
A1 Kuint, Ruth Cytter
A1 Ledder, Oren
A1 Navas-López, Victor M
A1 Sladek, Malgorzata
A1 Brückner, Annecarin
A1 Baldassano, Robert N
A1 Weiss, Batia
A1 Yerushalmi, Baruch
A1 Saeed, Shehzad A
A1 Hyams, Jeffrey
A1 Otley, Anthony
A1 Griffiths, Anne M
A1 Turner, Dan
A1 Greer, Mary-Louise C
A1 ImageKids Study group, 
AB Although magnetic resonance enterography (MRE) can accurately reflect ileal inflammation in pediatric Crohn disease (CD), there are no pediatric data on the accuracy of MRE to detect upper gastrointestinal tract (UGI) lesions. We aimed to compare MRE and esophagogastroduodenoscopy (EGD) in detecting the spectrum and severity of UGI disease in children. This is an ancillary study of the prospective multi-center ImageKids study focusing on pediatric MRE. EGD was performed within 2 weeks of MRE (at disease onset or thereafter) and explicitly scored by SES-CD modified for the UGI and physician global assessment. Local and central radiologists scored the UGI region of the MRE blinded to the EGD. Accuracy of MRE compared with EGD was examined using correlational coefficients (r) and area under receiver operating characteristic curves (AUC). One hundred and eighty-eight patients were reviewed (mean age 14 ± 1 years, 103 [55%] boys); 66 of 188 (35%) children had macroscopic ulcerations on EGD (esophagus, 13 [7%]; stomach, 34 [18%]; duodenum, 45 [24%]). Most children had aphthous ulcers, but 10 (5%) had larger ulcers (stomach, 2 [1%]; duodenum, 8 [4%]). There was no agreement between local and central radiologists on the presence or absence of UGI inflammation on MRE (Kappa = -0.02, P = 0.71). EGD findings were not accurately detected by MRE, read locally or centrally (r = -0.03 to 0.11, P = 0.18-0.88; AUC = 0.47-0.55, P = 0.53-1.00).No fistulae or narrowings were identified on either EGD or MRE. MRE cannot reliably assess the UGI in pediatric CD and cannot replace EGD for this purpose.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/11959
UL http://hdl.handle.net/10668/11959
LA en
DS RISalud
RD Apr 9, 2025