TY - JOUR AU - Verdugo-Escamilla, Cristobal AU - Alarcon-Payer, Carolina AU - Frontera, Antonio AU - Javier Acebedo-Martinez, Francisco AU - Dominguez-Martin, Alicia AU - Gomez-Morales, Jaime AU - Choquesillo-Lazarte, Duane PY - 2020 DO - 10.3390/cryst10121088 SN - 2073-4352 UR - http://hdl.handle.net/10668/19255 T2 - Crystals AB - The design of new multicomponent pharmaceutical materials that involve different active pharmaceutical ingredients (APIs), e.g., drug-drug cocrystals, is a novel and interesting approach to address new therapeutic challenges. In this work, the... LA - en PB - Mdpi KW - cocrystal KW - codrug KW - hydrochlorothiazide KW - caffeine KW - mechanochemical synthesis KW - Co-crystals KW - Solubility KW - Cocrystals KW - Design KW - Dissolution KW - Synthon KW - Program TI - Interconvertible Hydrochlorothiazide-Caffeine Multicomponent Pharmaceutical Materials: A Solvent Issue TY - research article VL - 10 ER -