RT Journal Article
T1 Systematic review of the efficacy of statins for the treatment of Alzheimer's disease.
A1 Mejías-Trueba, Marta
A1 Pérez-Moreno, María Antonia
A1 Fernández-Arche, María Ángeles
K1 Alzheimer's disease
K1 efficacy
K1 statins
K1 systematic review
AB Alzheimer's disease (AD) is the most common type of dementia. Recent studies have assessed the possibility of using statins as treatment for AD. However, their efficacy is not clear. In this study, we collected the most relevant information about the efficacy of statins for the treatment of AD. We conducted a systematic literature search using MEDLINE, EMBASE and The Cochrane Library. We included clinical trials, meta-analyses and systematic reviews that analysed the efficacy of statins in AD. We also extracted the characteristics and efficacy results of the studies selected. Of the 304 articles identified, 13 complied with the inclusion criteria. The scientific quality of studies was high and their results indicated that there were no significant differences in the main efficacy variables between statins and placebo treatment for AD. Therefore, according to the available scientific evidence, statins have not shown an improvement in cognition and do not appear to offer significant benefits to patients with AD.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/12121
UL http://hdl.handle.net/10668/12121
LA en
DS RISalud
RD Apr 8, 2025