RT Journal Article
T1 New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp
A1 Stierhof, Marc
A1 Hansen, Kine Ostnes
A1 Sharma, Mukesh
A1 Feussner, Klaus
A1 Subko, Karolina
A1 Diaz-Rullo, Fernando Fernandez
A1 Isaksson, Johan
A1 Perez-Victoria, Ignacio
A1 Clarke, David
A1 Hansen, Espen
A1 Jaspars, Marcel
A1 Tabudravu, Jioji N.
K1 Callipeltin
K1 Asteropus
K1 NMR
K1 LCMS
K1 Derivatisation
K1 Antiproliferative activity
K1 Papua-new-guinea
K1 Antifungal peptides
K1 Cyclic depsipeptide
K1 Theonella-swinhoei
K1 Latrunculia sp
AB Four new callipeltin A derivatives (N-Q) have been isolated from the Solomon Island marine sponge Asteropus sp. Their structures were established by spectroscopic techniques followed by acid hydrolysis and derivatisation of the free amino acids, and subsequent LCMS analysis of the derivatives. The compounds were evaluated for their activity against cancer cell lines A2058 (melanoma), HT-29 (colorectal adenocarcinoma) and MCF-7 (breast adenocarcinoma) and non-malignant MRC-5 fibroblast cells. While the acyclic callipeltins P and Q were inactive the cyclic callipeltins N and O showed significant cytotoxicity against all exposed cell lines with IC50 values as low as 0.16 mu M confirming the role of cyclic configuration in biological activity. (C) 2016 Elsevier Ltd. All rights reserved.
PB Pergamon-elsevier science ltd
SN 0040-4020
YR 2016
FD 2016-11-03
LK http://hdl.handle.net/10668/18887
UL http://hdl.handle.net/10668/18887
LA en
DS RISalud
RD Apr 11, 2025