RT Journal Article
T1 Assessment of medical management in Coronary Type 2 Diabetic patients with previous percutaneous coronary intervention in Spain: A retrospective analysis of electronic health records using Natural Language Processing.
A1 González-Juanatey, Carlos
A1 Anguita-Sá Nchez, Manuel
A1 Barrios, Vivencio
A1 Núñez-Gil, Iván
A1 Gómez-Doblas, Juan Josá
A1 García-Moll, Xavier
A1 Lafuente-Gormaz, Carlos
A1 Rollán-Gómez, María Jesús
A1 Peral-Disdie, Vicente
A1 Martínez-Dolz, Luis
A1 Rodríguez-Santamarta, Miguel
A1 Viñolas-Prat, Xavier
A1 Soriano-Colomé, Toni
A1 Muñoz-Aguilera, Roberto
A1 Plaza, Ignacio
A1 Curcio-Ruigómez, Alejandro
A1 Orts-Soler, Ernesto
A1 Segovia, Javier
A1 Maté, Claudia
A1 SAVANA Research Group, 
A1 Cequier, Ángel
AB Patients with type 2 diabetes (T2D) and stable coronary artery disease (CAD) previously revascularized with percutaneous coronary intervention (PCI) are at high risk of recurrent ischemic events. We aimed to provide real-world insights into the clinical characteristics and management of this clinical population, excluding patients with a history of myocardial infarction (MI) or stroke, using Natural Language Processing (NLP) technology. This is a multicenter, retrospective study based on the secondary use of 2014-2018 real-world data captured in the Electronic Health Records (EHRs) of 1,579 patients (0.72% of the T2D population analyzed; n = 217,632 patients) from 12 representative hospitals in Spain. To access the unstructured clinical information in EHRs, we used the EHRead® technology, based on NLP and machine learning. Major adverse cardiovascular events (MACE) were considered: MI, ischemic stroke, urgent coronary revascularization, and hospitalization due to unstable angina. The association between MACE rates and the variables included in this study was evaluated following univariate and multivariate approaches. Most patients were male (72.13%), with a mean age of 70.5±10 years. Regarding T2D, most patients were non-insulin-dependent T2D (61.75%) with high prevalence of comorbidities. The median (Q1-Q3) duration of follow-up was 1.2 (0.3-4.5) years. Overall, 35.66% of patients suffered from at least one MACE during follow up. Using a Cox Proportional Hazards regression model analysis, several independent factors were associated with MACE during follow up: CAD duration (p  Our results showed high rates of MACE in a large real-world series of PCI-revascularized patients with T2D and CAD with no history of MI or stroke. These data represent a potential opportunity to improve the clinical management of these patients.
YR 2022
FD 2022-02-10
LK http://hdl.handle.net/10668/20416
UL http://hdl.handle.net/10668/20416
LA en
DS RISalud
RD Apr 5, 2025