RT Journal Article
T1 Induced Dipoles and Possible Modulation of Wireless Effects in Implanted Electrodes. Effects of Implanting Insulated Electrodes on an Animal Test to Screen Antidepressant Activity.
A1 Perez-Caballero, Laura
A1 Carceller, Hector
A1 Nacher, Juan
A1 Teruel-Marti, Vicent
A1 Pujades, Eulalia
A1 Casañ-Pastor, Nieves
A1 Berrocoso, Esther
K1 Deep Brain Stimulation
K1 conducting materials
K1 depression
K1 feedback interactions
K1 implanted materials
K1 induced dipoles
K1 infralimbic cortex
K1 insulating
K1 rat
AB There is evidence that Deep Brain Stimulation (DBS) produces health benefits in patients even before initiating stimulation. Furthermore, DBS electrode insertion in rat infralimbic cortex (ILC) provokes antidepressant-like effects before stimulation, due to local inflammation and astrogliosis. Consequently, a significant effect of implanting electrodes is suspected. External fields, similar in magnitude to the brain's endogenous fields, induce electric dipoles in conducting materials, in turn influencing neural cell growth through wireless effects. To elucidate if such dipoles influence depressive-like behavior, without external stimulation, the comparative effect of conducting and insulated electrodes along with the glial response is studied in unstressed rats. Naïve and implanted rats with electrically insulated or uninsulated steel electrodes were evaluated in the modified forced swimming test and expression of ILC-glial markers was assessed. An antidepressant-like effect was observed with conducting but not with insulated electrodes. Gliosis was detected in both groups, but astroglial reactivity was larger near uninsulated electrodes. Thus, induced dipoles and antidepressant-like effects were only observed with conducting implants. Such correlation suggests that dipoles induced in electrodes by endogenous fields in turn induce neuron stimulation in a feedback loop between electrodes and neural system. Further research of the effects of unwired conducting implants could open new approaches to regulating neuronal function, and possibly treat neurological disorders.
SN 2077-0383
YR 2021
FD 2021-09-04
LK http://hdl.handle.net/10668/18506
UL http://hdl.handle.net/10668/18506
LA en
DS RISalud
RD Apr 19, 2025