RT Journal Article
T1 Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study).
A1 Rodriguez-Ortiz, M Encarnacion
A1 Gomez-Delgado, Francisco
A1 Arenas de Larriva, Antonio P
A1 Canalejo, Antonio
A1 Gomez-Luna, Purificacion
A1 Herencia, Carmen
A1 Lopez-Moreno, Javier
A1 Rodriguez, Mariano
A1 Lopez-Miranda, Jose
A1 Almaden, Yolanda
K1 Cardiovascular Diseases
K1 Carotid Arteries
K1 Carotid Artery Diseases
K1 Carotid Intima-Media Thickness
K1 Coronary Disease
AB This study aimed to ascertain whether there is an independent association between serum magnesium (Mg) and the Carotid Intima-Media Thickness (IMT-CC), a well-accepted atherosclerotic-biomarker surrogate of cardiovascular disease (CVD), in a population with high cardiovascular risk. Serum Mg and traditional atherosclerotic risk factors were recorded in 939 patients (mean age, 59.6 ± 0.3 years, 83.2% men) with coronary heart disease (CHD) enrolled in the CORDIOPREV trial. Serum Mg strongly associated with IMT-CC. Before adjusting for potential confounding factors, IMT-CC decreased by 0.111 ± 0.011 mm per mg/dl increase in serum Mg (p <0.001). After adjustment, the efect of Mg did not appear mediated through factors related to glucose metabolism, the lipid profle or the mineral metabolism and renal function. Multivariate models showed the lower Mg levels (quartile 1) as a strong independent factor contributing to IMT-CC along with age, sex, SBP, HDL-C, and diuretic use. Logistic regression analysis confrmed the predictive ability of serum Mg to diferentiate patients at higher atherosclerotic risk as defned by an IMT-CC≥1.0mm, yielding a OR for the lower quartile of 10.623(95%CI 2.311–48.845; P=0.002) and a ROC-derived cutof of 1.61mg/dl. Therefore, our fndings outline low serum magnesium as a possible independent risk factor for carotid atherosclerosis
PB Nature Publishing Group
YR 2019
FD 2019-05-13
LK http://hdl.handle.net/10668/14035
UL http://hdl.handle.net/10668/14035
LA en
NO Rodríguez-Ortiz ME, Gómez-Delgado F, Arenas de Larriva AP, Canalejo A, Gómez-Luna P, Herencia C, et al. Serum Magnesium is associated with Carotid Atherosclerosis in patients with high cardiovascular risk (CORDIOPREV Study). Sci Rep. 2019 May 29;9(1):8013
NO We would like to thank the EASP (Escuela Andaluza de Salud Publica), Granada, Spain, who performed the randomization process for this study. Te CORDIOPREV study is supported by Fundacion Patrimonio ComunalOlivarero. CITOLIVA and CEAS, Consejería de Economía, Innovación y Ciencia (CVI-7450); Ministerio de Economia (AGL2015-67896-P,PIE14/00005, PIE14/00031); Instituto de Salud Carlos III (FIS 14/00872; FIS 17/01024), co-funded with FEDER (European Regional Development Fund). Y.A. is supported by Nicolás Monardes Programme, Consejeria de Salud-SAS. CIBEROBN is an initiative of Instituto de Salud Carlos III.
DS RISalud
RD Apr 7, 2025