RT Journal Article
T1 Cancer Impacts Prognosis on Mortality in Patients with Acute Heart Failure: Analysis of the EPICTER Study.
A1 Méndez-Bailón, Manuel
A1 Lorenzo-Villalba, Noel
A1 Romero-Correa, Miriam
A1 Guisado-Espartero, Esther
A1 González-Soler, Juan
A1 Rugeles-Niño, Jessica
A1 Sebastián-Leza, Angel
A1 Ceresuela-Eito, Luis
A1 Romaní-Costa, Verónica
A1 Quesada-Simón, Angustias
A1 Soler-Rangel, Llanos
A1 Herrero-Domingo, Almudena
A1 Díez-García, Luis
A1 Alcalá-Pedrajas, José
A1 Villalonga-Comas, María
A1 Andrès, Emmanuel
A1 Gudiñ-Aguirre, Diego
A1 Formiga, Francesc
A1 Aramburu-Bodas, Oscar
A1 Arias-Jiménez, Jose
A1 Salamanca-Bautista, Prado
A1 On Behalf Of Epicter Study Group, 
K1 acute heart failure
K1 cancer
K1 mortality
AB Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. The EPICTER study ("Epidemiological survey of advanced heart failure") is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan-Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (p = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, p = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, p = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), p = 0.046. Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis.
SN 2077-0383
YR 2022
FD 2022-01-24
LK http://hdl.handle.net/10668/21236
UL http://hdl.handle.net/10668/21236
LA en
DS RISalud
RD Apr 9, 2025