TY - JOUR AU - Montesinos, Pau AU - Díaz-Mediavilla, Joaquín AU - Debén, Guillermo AU - Prates, Virginia AU - Tormo, Mar AU - Rubio, Vicente AU - Pérez, Inmaculada AU - Fernández, Isolda AU - Viguria, Maricruz AU - Rayón, Chelo AU - González, José AU - Serna, Javier de la AU - Esteve, Jordi AU - Bergua, Juan M AU - Rivas, Concha AU - González, Marcos AU - González, Jose D AU - Negri, Silvia AU - Brunet, Salut AU - Lowenberg, Bob AU - Sanz, Miguel A PY - 2009 DO - 10.3324/haematol.2009.007872 SN - 0390-6078 UR - http://hdl.handle.net/10668/1276 T2 - Haematologica AB - BACKGROUNDThe prevalence of and risk factors for central nervous system recurrence in patients with acute promyelocytic leukemia are not well established and remain a controversial matter.DESIGN AND METHODSBetween 1996 and 2005, 739 patients with... LA - en PB - Ferrata Storti Foundation KW - Acute promyelocytic leukemia KW - Central nervous system relapse KW - All-trans retinoic acid KW - Idarubicin KW - Prognostic factors KW - Neoplasias del sistema nervioso central KW - Antibióticos antineoplásicos KW - Leucemia promielocítica aguda KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Antibiotics, Antineoplastic KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms KW - Medical Subject Headings::Check Tags::Female KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Idarubicin KW - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors KW - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Acyclic::Alkenes::Polyenes::Carotenoids::Retinoids KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adolescent TI - Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy without intrathecal prophylaxis. TY - research article ER -