RT Journal Article
T1 Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals.
A1 Rivera, Margarita
A1 Locke, Adam E
A1 Corre, Tanguy
A1 Czamara, Darina
A1 Wolf, Christiane
A1 Ching-Lopez, Ana
A1 Milaneschi, Yuri
A1 Kloiber, Stefan
A1 Cohen-Woods, Sarah
A1 Rucker, James
A1 Aitchison, Katherine J
A1 Bergmann, Sven
A1 Boomsma, Dorret I
A1 Craddock, Nick
A1 Gill, Michael
A1 Holsboer, Florian
A1 Hottenga, Jouke-Jan
A1 Korszun, Ania
A1 Kutalik, Zoltan
A1 Lucae, Susanne
A1 Maier, Wolfgang
A1 Mors, Ole
A1 Müller-Myhsok, Bertram
A1 Owen, Michael J
A1 Penninx, Brenda W J H
A1 Preisig, Martin
A1 Rice, John
A1 Rietschel, Marcella
A1 Tozzi, Federica
A1 Uher, Rudolf
A1 Vollenweider, Peter
A1 Waeber, Gerard
A1 Willemsen, Gonneke
A1 Craig, Ian W
A1 Farmer, Anne E
A1 Lewis, Cathryn M
A1 Breen, Gerome
A1 McGuffin, Peter
AB BackgroundDepression and obesity are highly prevalent, and major impacts on public health frequently co-occur. Recently, we reported that having depression moderates the effect of the FTO gene, suggesting its implication in the association between depression and obesity.AimsTo confirm these findings by investigating the FTO polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.MethodThe sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts. Linear regression models were performed to test for association between rs9939609 and body mass index (BMI), and for the interaction between rs9939609 and depression status for an effect on BMI. Fixed and random effects meta-analyses were performed using METASOFT.ResultsIn the replication cohorts, we observed a significant interaction between FTO, BMI and depression with fixed effects meta-analysis (β = 0.12, P = 2.7 × 10-4) and with the Han/Eskin random effects method (P = 1.4 × 10-7) but not with traditional random effects (β = 0.1, P = 0.35). When combined with the discovery cohorts, random effects meta-analysis also supports the interaction (β = 0.12, P = 0.027) being highly significant based on the Han/Eskin model (P = 6.9 × 10-8). On average, carriers of the risk allele who have depression have a 2.2% higher BMI for each risk allele, over and above the main effect of FTOConclusionsThis meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI. The findings provide a useful starting point in understanding the biological mechanism involved in the association between obesity and depression.
YR 2017
FD 2017-06-22
LK http://hdl.handle.net/10668/11335
UL http://hdl.handle.net/10668/11335
LA en
DS RISalud
RD Apr 19, 2025