RT Journal Article
T1 Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
A1 Toribio, Maria Jose
A1 Priego-Capote, Feliciano
A1 Perez-Gomez, Beatriz
A1 Fernandez de Larrea-Baz, Nerea
A1 Ruiz-Moreno, Emma
A1 Castello, Adela
A1 Lucas, Pilar
A1 Sierra, Maria angeles
A1 Pino, Marina Nieves
A1 Martinez-Cortes, Mercedes
A1 Luque de Castro, Maria Dolores
A1 Lope, Virginia
A1 Pollan, Marina
K1 Vit D-3
K1 25(OH)D-3
K1 1,25(OH)(2)D-3
K1 24,25(OH)(2)D-3
K1 vitamin D metabolite ratios
K1 D deficiency
K1 Population
K1 Obesity
K1 Sample
K1 Risk
AB The most representative indicator of vitamin D status in clinical practice is 25(OH)D-3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D-3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)(2)D-3/25(OH)D-3) and a higher R4 (24,25(OH)(2)D-3/1,25(OH)(2)D-3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D-3/Vit D-3) and R3 (24,25(OH)(2)D-3/25(OH)D-3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
PB Mdpi
YR 2021
FD 2021-11-01
LK https://hdl.handle.net/10668/25639
UL https://hdl.handle.net/10668/25639
LA en
DS RISalud
RD Apr 12, 2025