TY - JOUR AU - del Rio, Carmen AU - Navarrete, Carmen AU - Collado, Juan A AU - Bellido, M Luz AU - Gomez-Cañas, Maria AU - Pazos, M Ruth AU - Fernandez-Ruiz, Javier AU - Pollastro, Federica AU - Appendino, Giovanni AU - Calzado, Marco A AU - Cantarero, Irene AU - Muñoz, Eduardo PY - 2016 DO - 10.1038/srep21703 UR - http://hdl.handle.net/10668/9845 T2 - Scientific reports AB - Scleroderma is a group of rare diseases associated with early and transient inflammation and vascular injury, followed by fibrosis affecting the skin and multiple internal organs. Fibroblast activation is the hallmark of scleroderma, and disrupting... LA - en PB - Nature Publishing Group KW - Mice KW - NIH 3T3 Cells KW - PPAR gamma KW - Receptor, Cannabinoid, CB2 KW - Scleroderma, Localized KW - Signal Transduction KW - Animals KW - Bleomycin KW - Cannabinoids KW - Cell Differentiation KW - Disease Models, Animal KW - Gene Expression Regulation KW - HEK293 Cells KW - Humans KW - Hydroquinones TI - The cannabinoid quinol VCE-004.8 alleviates bleomycin-induced scleroderma and exerts potent antifibrotic effects through peroxisome proliferator-activated receptor-γ and CB2 pathways. TY - research article VL - 6 ER -