TY - JOUR AU - Boza-Serrano, Antonio AU - Ruiz, Rocío AU - Sanchez-Varo, Raquel AU - García-Revilla, Juan AU - Yang, Yiyi AU - Jimenez-Ferrer, Itzia AU - Paulus, Agnes AU - Wennström, Malin AU - Vilalta, Anna AU - Allendorf, David AU - Davila, Jose Carlos AU - Stegmayr, John AU - Jiménez, Sebastian AU - Roca-Ceballos, Maria A AU - Navarro-Garrido, Victoria AU - Swanberg, Maria AU - Hsieh, Christine L AU - Real, Luis M AU - Englund, Elisabet AU - Linse, Sara AU - Leffler, Hakon AU - Nilsson, Ulf J AU - Brown, Guy C AU - Gutierrez, Antonia AU - Vitorica, Javier AU - Venero, Jose Luis AU - Deierborg, Tomas PY - 2019 DO - 10.1007/s00401-019-02013-z UR - http://hdl.handle.net/10668/13855 T2 - Acta neuropathologica AB - Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks.... LA - en KW - Alzheimer’s disease (AD) KW - Amyloid aggregation KW - Galectin-3 KW - Inflammation KW - Microglia KW - TREM2 KW - Alzheimer Disease KW - Amyloid KW - Amyloid beta-Peptides KW - Animals KW - Cells, Cultured KW - Disease Models, Animal KW - Female KW - Galectin 3 KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Hippocampus KW - Humans KW - Inflammation KW - Male KW - Maze Learning KW - Membrane Glycoproteins KW - Mice KW - Mice, Inbred C57BL KW - Mice, Knockout KW - Mice, Transgenic KW - Microglia KW - Molecular Targeted Therapy KW - Polymorphism, Single Nucleotide KW - Protein Aggregation, Pathological KW - Receptors, Immunologic TI - Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. TY - research article VL - 138 ER -