RT Journal Article
T1 Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults
A1 Montes-de-Oca-García, Adrián
A1 Perez-Bey, Alejandro
A1 Velázquez-Díaz, Daniel
A1 Corral-Pérez, Juan
A1 Opazo-Díaz, Edgardo
A1 Rebollo-Ramos, María
A1 Gómez-Gallego, Félix
A1 Cuenca-García, Magdalena
A1 Casals, Cristina
A1 Ponce-González, Jesús G.
K1 Genetic association studies
K1 Heart diseases
K1 Lipid metabolism
K1 Healthy lifestyle
K1 Angiotensin-converting enzyme
K1 Obesity
K1 Estudios de asociación genética
K1 Cardiopatías
K1 Metabolismo de los lípidos
K1 Estilo de vida saludable
K1 Peptidil-Dipeptidasa A
K1 Obesidad
AB There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespiratory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymorphism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO.
PB MDPI
SN 1661-7827
YR 2021
FD 2021-03-26
LK http://hdl.handle.net/10668/4471
UL http://hdl.handle.net/10668/4471
LA en
NO Montes-de-Oca-García A, Perez-Bey A, Velázquez-Díaz D, Corral-Pérez J, Opazo-Díaz E, Rebollo-Ramos M, et al. Influence of ACE Gene I/D Polymorphism on Cardiometabolic Risk, Maximal Fat Oxidation, Cardiorespiratory Fitness, Diet and Physical Activity in Young Adults. Int J Environ Res Public Health. 2021 Mar 26;18(7):3443
DS RISalud
RD Apr 11, 2025