%0 Journal Article
%A Loucera, Carlos
%A Perez-Florido, Javier
%A Casimiro-Soriguer, Carlos S
%A Ortuño, Francisco M
%A Carmona, Rosario
%A Bostelmann, Gerrit
%A Martinez-Gonzalez, L Javier
%A Muñoyerro-Muñiz, Dolores
%A Villegas, Roman
%A Rodriguez-Baño, Jesus
%A Romero-Gomez, Manuel
%A Lorusso, Nicola
%A Garcia-Leon, Javier
%A Navarro-Mari, Jose M
%A Camacho-Martinez, Pedro
%A Merino-Diaz, Laura
%A Salazar, Adolfo de
%A Viñuela, Laura
%A Lepe, Jose A
%A Garcia, Federico
%A Dopazo, Joaquin
%T Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival.
%D 2022
%U http://hdl.handle.net/10668/21601
%X More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the impact on COVID-19 severity and patient survival is uncertain. A total of 764 SARS-CoV-2 genomes, sequenced from COVID-19 patients, hospitalized from 19th February 2020 to 30 April 2021, along with their clinical data, were used for survival analysis. A significant association of B.1.1.7, the alpha lineage, with patient mortality (log hazard ratio (LHR) = 0.51, C.I. = [0.14,0.88]) was found upon adjustment by all the covariates known to affect COVID-19 prognosis. Moreover, survival analysis of mutations in the SARS-CoV-2 genome revealed 27 of them were significantly associated with higher mortality of patients. Most of these mutations were located in the genes coding for the S, ORF8, and N proteins. This study illustrates how a combination of genomic and clinical data can provide solid evidence for the impact of viral lineage on patient survival.
%K COVID-19
%K SARS-CoV-2
%K phylogeny
%K survival
%K virus genome
%~