TY - JOUR AU - Sharkawy, Rasha El AU - Bayoumi, Ali AU - Metwally, Mayada AU - Mangia, Alessandra AU - Berg, Thomas AU - Romero-Gomez, Manuel AU - Abate, Maria Lorena AU - Irving, William L AU - Sheridan, David AU - Dore, Gregory J AU - Spengler, Ulrich AU - Lampertico, Pietro AU - Bugianesi, Elisabetta AU - Weltman, Martin AU - Mollison, Lindsay AU - Cheng, Wendy AU - Riordan, Stephen AU - Santoro, Rosanna AU - Gallego-Durán, Rocío AU - Fischer, Janett AU - Nattermann, Jacob AU - D'Ambrosio, Roberta AU - McLeod, Duncan AU - Powell, Elizabeth AU - Latchoumanin, Olivier AU - Thabet, Khaled AU - Najim, Mustafa A M AU - Douglas, Mark W AU - Liddle, Christopher AU - Qiao, Liang AU - George, Jacob AU - Eslam, Mohammed AU - International Liver Disease Genetics Consortium (ILDGC) PY - 2019 DO - 10.1038/s41598-018-35736-2 UR - http://hdl.handle.net/10668/13519 T2 - Scientific reports AB - Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The... LA - en KW - Female KW - GTPase-Activating Proteins KW - Hepatitis C, Chronic KW - Histocompatibility Antigens Class I KW - Humans KW - Liver KW - Liver Cirrhosis KW - Male KW - Polymorphism, Single Nucleotide KW - Signal Transduction KW - Transforming Growth Factor beta1 TI - A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms. TY - research article VL - 9 ER -