RT Journal Article
T1 The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens
A1 Rodriguez-Barbosa, Jose-Ignacio
A1 Schneider, Pascal
A1 Graca, Luis
A1 Bühler, Leo
A1 Perez-Simon, Jose-Antonio
A1 del Rio, Maria-Luisa
K1 Regulatory T cells
K1 Lymphopenia
K1 Homeostatic proliferation
K1 Transplantation
K1 TNF/TNF receptors
K1 Graft-versus-host disease
K1 Graft rejection
K1 Linfocitos T reguladores
K1 Linfopenia
K1 Proliferación celular
K1 Trasplante
K1 Receptores del factor de necrosis tumoral
K1 Enfermedad injerto contra huésped
K1 Rechazo de injerto
AB Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self and non-self through cell-intrinsic and cell-extrinsic mechanisms. Peripheral Tregs survival and clonal expansion largely depend on IL-2 and access to co-stimulatory signals such as CD28. Engagement of tumor necrosis factor receptor (TNFR) superfamily members, in particular TNFR2 and DR3, contribute to promote peripheral Tregs expansion and sustain their survival. This property can be leveraged to enhance tolerance to allogeneic transplants by tipping the balance of Tregs over conventional T cells during the course of immune reconstitution. This is of particular interest in peri-transplant tolerance induction protocols in which T cell depletion is applied to reduce the frequency of alloreactive T cells or in conditioning regimens that allow allogeneic bone marrow transplantation. These conditioning regimens are being implemented to limit long-term side effects of continuous immunosuppression and facilitate the establishment of a state of donor-specific tolerance. Lymphopenia-induced homeostatic proliferation in response to cytoreductive conditioning is a window of opportunity to enhance preferential expansion of Tregs during homeostatic proliferation that can be potentiated by agonist stimulation of TNFR.
PB MDPI
YR 2020
FD 2020-05-09
LK http://hdl.handle.net/10668/3738
UL http://hdl.handle.net/10668/3738
LA en
NO Rodriguez-Barbosa JI, Schneider P, Graca L, Bühler L, Perez-Simon JA, del Rio ML. The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens. Int J Mol Sci. 2020 May 9;21(9):3347
DS RISalud
RD Apr 12, 2025