TY  - JOUR
AU  - Muñoz, Miguel
AU  - Coveñas, Rafael
PY  - 2020
DO  - 10.3390/jcm9061659
UR  - http://hdl.handle.net/10668/3714
T2  - Journal of Clinical Medicine
AB  - Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy. To treat the disease successfully, new therapeutic strategies are urgently needed. One of these strategies can be the use of neurokinin-1 receptor (NK-1R) antagonists (e.g.,...
LA  - en
PB  - MDPI
KW  - Substance P
KW  - NK-1R
KW  - AML
KW  - Aprepitant
KW  - Anti-leukemic
KW  - Apoptosis
KW  - Non-solid tumor
KW  - Sustancia P
KW  - Receptores de neuroquinina-1
KW  - Leucemia mieloide aguda
KW  - Neoplasias hematológicas
KW  - Antineoplásicos
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators::Autacoids::Kinins::Tachykinins::Substance P
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Tachykinin::Receptors, Neurokinin-1
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Myeloid::Leukemia, Myeloid, Acute
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Hematologic Neoplasms
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Up-Regulation
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress
KW  - Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Protein Isoforms
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics
KW  - Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain
TI  - The Neurokinin-1 Receptor Antagonist Aprepitant, a New Drug for the Treatment of Hematological Malignancies: Focus on Acute Myeloid Leukemia
TY  - review article
ER  -