RT Journal Article
T1 Large-scale assessment of aortic stenosis: facing the next cardiac epidemic?
A1 Ramos, Javier
A1 Monteagudo, Juan Manuel
A1 González-Alujas, Teresa
A1 Fuentes, María Eugenia
A1 Sitges, Marta
A1 Peña, María Luisa
A1 Carrasco-Chinchilla, Fernando
A1 Echeverría, Tomás
A1 Bouzas, Alberto
A1 Forteza Alberti, José Francisco
A1 Mesa, Dolores
A1 De La Hera, Jesús María
A1 Zamorano, José Luis
AB Aortic stenosis (AS) is the most frequent valvular disease in developed countries. As society grows older, the prevalence of AS increases. However, the real burden, current aetiology, severity distribution, and echocardiographic patterns of AS are not fully clear. The aim of the present study is to provide an accurate overall picture of AS, focusing on its epidemiology, aetiology, and echocardiographic features. A total of 29 502 consecutive echocardiograpies were prospectively included in this multicentre study. The present sample was composed of patients with advanced age (mean 75.2 years) and similar gender distribution. High proportion (7.2%) showed any grade of AS, with important number of patients (2.8%) presenting severe AS, most of them aged 75 years or more. Coexisting valvular disease appeared in almost half of the sample (49.6%), being the most frequently diagnosed aortic regurgitation (AR) (22%) followed by mitral regurgitation (MR) (15.6%). Degenerative aetiology was found in the vast majority (93.4%) of the studies whereas rheumatic is currently infrequent (3.35%). Low flow-low gradient (LFLG) appeared in 24.6% of patients with severe AS. Atrial fibrillation (23.1% vs. 11.6%; P = 0.002), MR (23.3% vs. 15.1%; P = 0.018), and right ventricle dysfunction (13.3% vs. 5.2%; P = 0.003) appeared frequently in LFLG group. Burden of AS is higher than previously assumed. Degenerative aetiology is the main cause of AS. Most of the patients are elder with high prevalence of significant co-existing valvular disease. LFLG severe AS is present in an important proportion of patients, showing high grade of left ventricle remodelling.
YR 2018
FD 2018
LK http://hdl.handle.net/10668/11681
UL http://hdl.handle.net/10668/11681
LA en
DS RISalud
RD May 9, 2025