RT Journal Article
T1 SEOM Clinical Guideline of management of soft-tissue sarcoma (2016).
A1 López-Pousa, A
A1 Martin Broto, J
A1 Martinez Trufero, J
A1 Sevilla, I
A1 Valverde, C
A1 Alvarez, R
A1 Carrasco Alvarez, J A
A1 Cruz Jurado, J
A1 Hindi, N
A1 Garcia Del Muro, X
K1 Clinical guidelines
K1 Sarcoma
K1 Soft-tissue tumors
K1 Uncommon tumors
AB Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.
YR 2016
FD 2016
LK http://hdl.handle.net/10668/10655
UL http://hdl.handle.net/10668/10655
LA en
DS RISalud
RD Apr 7, 2025