%0 Journal Article
%A López-Pousa, A
%A Martin Broto, J
%A Martinez Trufero, J
%A Sevilla, I
%A Valverde, C
%A Alvarez, R
%A Carrasco Alvarez, J A
%A Cruz Jurado, J
%A Hindi, N
%A Garcia Del Muro, X
%T SEOM Clinical Guideline of management of soft-tissue sarcoma (2016).
%D 2016
%U http://hdl.handle.net/10668/10655
%X Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.
%K Clinical guidelines
%K Sarcoma
%K Soft-tissue tumors
%K Uncommon tumors
%~