RT Journal Article
T1 Are infections in children with juvenile idiopathic arthritis more frequent than in healthy children? A prospective multicenter observational study.
A1 Udaondo, Clara
A1 Nuñez-Cuadros, Esmeralda
A1 Murias, Sara
A1 Remesal, Agustin
A1 Alcobendas, Rosa
A1 Guerrero, Concepcion
A1 Guillen-Martin, Sara
A1 Escuredo, Marta
A1 Aleo, Esther
A1 Alonso, Daniel
A1 Tagarro, Alfredo
A1 De-Santiago, Eloisa
A1 Camacho-Lovillo, Marisol
A1 Diaz, Fatima
A1 Arenas, Dolores
A1 Camacho, Pilar
A1 Lirola, Maria Jose
A1 Diaz-Almiron, Mariana
A1 Calvo, Cristina
K1 Infection rate
K1 Infections
K1 Juvenile idiopathic arthritis (JIA)
K1 Methotrexate
K1 Safety
K1 Tumor necrosis alpha antagonist
K1 Área de Gestión Sanitaria Sur de Sevilla
AB Children with juvenile idiopathic arthritis (JIA) might be at a higher risk of infection. Our objectives are to describe and compare infection rates in patients with JIA vs. healthy patients. A prospective, multicenter observational study was performed in Spain from January 2017 to June 2019. Patients with JIA from 7 participating hospitals and children without JIA (siblings of patients with JIA, and non-JIA children from primary health centers) were followed up with quarterly questionnaires to record infection episodes. Tuberculosis, herpes zoster, and infections requiring hospital admission were considered severe infections. Rates of infection (episodes/patient/year) were compared using a generalized estimating equations model. A total of 371 children (181 with and 190 without JIA) were included. The median age was 8.8 years (IQR 5.5-11.3); 75% of the patients with JIA received immunosuppressive treatment (24% methotrexate, 22% biologic, 26% both). A total of 667 infections were recorded; 15 (2.2%) were considered severe. The infection rate was 1.31 (95%CI 1.1-1.5) in JIA and 1.12 (95%CI 0.9-1.3) in non-JIA participants (p = 0.19). Age  We found no differences in the infection rate or infection severity between patients with and without JIA. Most infections were mild. An age younger than 4 years increased the infection risk in both groups. Higher disease activity was associated with a higher infection rate.
PB Frontiers Research Foundation
SN 2296-2360
YR 2022
FD 2022-08-11
LK http://hdl.handle.net/10668/20695
UL http://hdl.handle.net/10668/20695
LA en
NO Udaondo C, Núñez Cuadros E, Murias S, Remesal A, Alcobendas R, Guerrero C, et al. Are infections in children with juvenile idiopathic arthritis more frequent than in healthy children? A prospective multicenter observational study. Front Pediatr. 2022 Aug 11;10:917731
DS RISalud
RD Apr 7, 2025