RT Journal Article
T1 Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report
A1 Valdivielso Felices, Pedro
A1 Rioja, José
A1 García-Arias, Carlota
A1 Sánchez-Chaparro, Miguel Ángel
A1 González-Santos, Pedro
K1 Glucemia
K1 Omacor
K1 Eicosapentaenoic Acid
K1 Docosahexaenoic Acids
K1 Fluvastatin
K1 Apolipoproteína B-48
K1 Presión Arterial
K1 Terapia Combinada
K1 Diabetes Mellitus Tipo 2
K1 Dietoterapia
K1 Ácidos Docosahexaenoicos
K1 Combinación de Medicamentos
K1 Ácido Eicosapentaenoico
K1 Ácidos Grasos Monoinsaturados
K1 Hemoglobina A Glucosilada
K1 Hiperlipidemia Familiar Combinada
K1 Hipertensión
K1 Antihipertensivos
K1 Lípidos
K1 Hipolipemiantes
AB BACKGROUNDMixed hyperlipidemia is common in patients with diabetes. Statins, the choice drugs, are effective at reducing lipoproteins that contain apolipoprotein B100, but they fail to exert good control over intestinal lipoproteins, which have an atherogenic potential. We describe the effect of prescription omega 3 fatty acids on the intestinal lipoproteins in patients with type 2 diabetes who were already receiving fluvastatin 80 mg per day.METHODSPatients with type 2 diabetes and mixed hyperlipidemia were recruited. Fasting lipid profile was taken when patients were treated with diet, diet plus 80 mg of fluvastatin and diet plus fluvastatin 80 mg and 4 g of prescription omega 3 fatty acids. The intestinal lipoproteins were quantified by the fasting concentration of apolipoprotein B48 using a commercial ELISA.RESULTSThe addition of 4 g of prescription omega 3 was followed by significant reductions in the levels of triglycerides, VLDL triglycerides and the triglyceride/HDL cholesterol ratio, and an increase in HDL cholesterol (P < 0.05). Fluvastatin induced a reduction of 26% in B100 (P < 0.05) and 14% in B48 (NS). However, the addition of omega 3 fatty acids enhanced this reduction to 32% in B100 (NS) and up to 36% in B48 (P < 0.05).CONCLUSIONOur preliminary findings therefore suggest an additional benefit on postprandial atherogenic particles when omega 3 fatty acids are added to standard treatment with fluvastatin.
PB BIOMED CENTRAL
YR 2009
FD 2009-01-08
LK http://hdl.handle.net/10668/678
UL http://hdl.handle.net/10668/678
LA en
NO Valdivielso P, Rioja J, García-Arias C, Sánchez-Chaparro MA, González-Santos P. Omega 3 fatty acids induce a marked reduction of apolipoprotein B48 when added to fluvastatin in patients with type 2 diabetes and mixed hyperlipidemia: a preliminary report. Cardiovasc Diabetol. 2009;8:1
NO Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 11, 2025