TY  - JOUR
AU  - González-Dominguez, Alvaro
AU  - Montañez, Raúl
AU  - Castejón-Vega, Beatriz
AU  - Nuñez-Vasco, Jéssica
AU  - Lendines-Cordero, Débora
AU  - Wang, Chun
AU  - Mbalaviele, Gabriel
AU  - Navarro-Pando, José M.
AU  - Alcocer-Gómez, Elísabet
AU  - Cordero, Mario D.
PY  - 2021
DO  - 10.15252/emmm.202114012
UR  - http://hdl.handle.net/10668/4355
T2  - EMBO Molecular Medicine
AB  - Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson-Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS skin...
LA  - en
PB  - EMBO Press
KW  - Aging
KW  - NLRP3
KW  - Inflammasome
KW  - Progeria
KW  - Caspase 1
KW  - Longevity
KW  - Fibroblasts
KW  - Phenotype
KW  - Lamin A
KW  - Envejecimiento
KW  - Proteína con dominio pirina 3 de la familia NLR
KW  - Inflamasomas
KW  - Caspase 1
KW  - Longevidad
KW  - Fibroblastos
KW  - Fenotipo
KW  - Lamina tipo A
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals
KW  - Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Multiprotein Complexes::Inflammasomes
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Nuclear Matrix-Associated Proteins::Lamins::Lamin Type A
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Longevity
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
KW  - Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Genetic Diseases, Inborn::Metabolism, Inborn Errors::Progeria
KW  - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Initiator::Caspase 1
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
KW  - Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Fibroblasts
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal
TI  - Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria
TY  - research article
ER  -