RT Journal Article
T1 Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis
A1 Gu, Shoujun
A1 Olszewski, Rafal
A1 Nelson, Lacey
A1 Gallego-Martinez, Alvaro
A1 Lopez-Escamez, Jose Antonio
A1 Hoa, Michael
K1 Stria vascularis
K1 Single-cell, nucleus
K1 RNA-seq
K1 Meniere’s, ion homeostasis
K1 Meniere’s disease
K1 Endolymph
K1 Endolymphatic Hydrops
K1 Cochlea
K1 Hearing Loss
K1 Systematic Review
K1 Homeostasis
K1 Estría vascular
K1 Enfermedad de Meniere
K1 Endolinfa
K1 Hidropesía endolinfática
K1 Cóclea
K1 Pérdida auditiva
K1 Revisión sistemática
AB The stria vascularis generates the endocochlear potential and is involved in processes that underlie ionic homeostasis in the cochlear endolymph, both which play essential roles in hearing. The histological hallmark of Meniere's disease (MD) is endolymphatic hydrops, which refers to the bulging or expansion of the scala media, which is the endolymph-containing compartment of the cochlea. This histologic hallmark suggests that processes that disrupt ion homeostasis or potentially endocochlear potential may underlie MD. While treatments exist for vestibular symptoms related to MD, effective therapies for hearing fluctuation and hearing loss seen in MD remain elusive. Understanding the potential cell types involved in MD may inform the creation of disease mouse models and provide insight into underlying mechanisms and potential therapeutic targets. For these reasons, we compare published datasets related to MD in humans with our previously published adult mouse stria vascularis single-cell and single-nucleus RNA-Seq datasets to implicate potentially involved stria vascularis (SV) cell types in MD. Finally, we provide support for these implicated cell types by demonstrating co-expression of select candidate genes for MD within SV cell types.
PB Frontiers
YR 2021
FD 2021-02-05
LK http://hdl.handle.net/10668/4144
UL http://hdl.handle.net/10668/4144
LA en
NO Gu S, Olszewski R, Nelson L, Gallego-Martinez A, Lopez-Escamez JA, Hoa M. Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis. Front Neurol. 2021 Feb 5;12:630561.
DS RISalud
RD Apr 5, 2025