RT Journal Article
T1 Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort.
A1 Butt, Julia
A1 Jenab, Mazda
A1 Werner, Jill
A1 Fedirko, Veronika
A1 Weiderpass, Elisabete
A1 Dahm, Christina C
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Boutron-Ruault, Marie-Christine
A1 Rothwell, Joseph A
A1 Severi, Gianluca
A1 Kaaks, Rudolf
A1 Turzanski-Fortner, Renée
A1 Aleksandrova, Krasimira
A1 Schulze, Matthias
A1 Palli, Domenico
A1 Pala, Valeria
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Bueno-de-Mesquita, Bas
A1 Van Gils, Carla H
A1 Gram, Inger Torhild
A1 Lukic, Marko
A1 Sala, Núria
A1 Sánchez Pérez, María José
A1 Ardanaz, Eva
A1 Chirlaque, María-Dolores
A1 Palmquist, Richard
A1 Löwenmark, Thyra
A1 Travis, Ruth C
A1 Heath, Alicia
A1 Cross, Amanda J
A1 Freisling, Heinz
A1 Zouiouich, Semi
A1 Aglago, Elom
A1 Waterboer, Tim
A1 Hughes, David J
K1 Colorectal cancer
K1 Escherichia coli
K1 bacteroides fragilis
K1 prospective
K1 serology
AB Experimental evidence has implicated genotoxic Escherichia coli (E. coli) and enterotoxigenic Bacteroides fragilis (ETBF) in the development of colorectal cancer (CRC). However, evidence from epidemiological studies is sparse. We therefore assessed the association of serological markers of E. coli and ETBF exposure with odds of developing CRC in the European Prospective Investigation into Nutrition and Cancer (EPIC) study.Serum samples of incident CRC cases and matched controls (n = 442 pairs) were analyzed for immunoglobulin (Ig) A and G antibody responses to seven E. coli proteins and two isoforms of the ETBF toxin via multiplex serology. Multivariable-adjusted conditional logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association of sero-positivity to E. coli and ETBF with CRC.The IgA-positivity of any of the tested E. coli antigens was associated with higher odds of developing CRC (OR: 1.42; 95% CI: 1.05-1.91). Dual-positivity for both IgA and IgG to E. coli and ETBF was associated with >1.7-fold higher odds of developing CRC, with a significant association only for IgG (OR: 1.75; 95% CI: 1.04, 2.94). This association was more pronounced when restricted to the proximal colon cancers (OR: 2.62; 95% CI: 1.09, 6.29) compared to those of the distal colon (OR: 1.24; 95% CI: 0.51, 3.00) (pheterogeneity = 0.095). Sero-positivity to E. coli and ETBF was associated with CRC development, suggesting that co-infection of these bacterial species may contribute to colorectal carcinogenesis. These findings warrant further exploration in larger prospective studies and within different population groups.
YR 2021
FD 2021
LK https://hdl.handle.net/10668/24654
UL https://hdl.handle.net/10668/24654
LA en
DS RISalud
RD Apr 17, 2025